Why is a depot injection called a depot?
Depot. A depot injection is an injection, usually subcutaneous, intradermal, or intramuscular, that deposits a drug in a localized mass, called a depot, from which it is gradually absorbed by surrounding tissue.
Where did antipsychotics originate?
The History Of First Generation Antipsychotics The use of antipsychotics as medication began in 1933 in France. The research around developing antihistamines evolved into the introduction of promethazine. This drug produced sedative side effects, so doctors started prescribing it before surgeries as a calming agent.
What does depot mean in drugs?
A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics.
What is a depot antipsychotic?
What are ‘depot’ antipsychotics? A depot injection is a slow-release, slow-acting form of your medication. It isn’t a different medication – it’s the same as the antipsychotic medication you’re used to taking in tablet or liquid form, but it’s given by injection instead.
Is clozapine a depot injection?
It is administered by deep intramuscular injection into the gluteal muscle. The injection is painful and the maximum volume that can be injected into each site is 4ml (100mg). For doses greater than 100mg daily (beyond the scope of this protocol), the dose may be divided and administered into two sites.
What is the advantage of an antipsychotic depot injection?
Abstract. The main advantage of depot antipsychotic medication is that it overcomes the problem of covert noncompliance. Patients receiving depot treatment who refuse their injection or fail to receive it for any other reason can be immediately identified and appropriate action taken.
When were antipsychotic drugs invented?
First-generation antipsychotics (e.g. chlorpromazine), known as typical antipsychotics, were first introduced in the 1950s, and others were developed until the early 1970s.
Who invented antipsychotic drugs?
In 1957 three key figures involved in this story (Henri Laborit, Pierre Deniker and the Canadian psychiatrist Heinz Lehmann) were jointly awarded a Lasker Award by the American Public Health Association in recognition of their work in introducing chlorpromazine as a treatment for schizophrenia.
Where is the word depot from?
French
Depot came into English from the French word dépôt, meaning “a deposit, place of deposit.” A depot can be a place like a warehouse where items are temporarily deposited, but we also use it for a train or bus station. In this case, think of it as a place where a many passengers are being temporarily housed.
Why are depot antipsychotics used?
Long-acting depot antipsychotic medications were developed in the 1960s to promote adherence in people with recurrent psychotic disorders, including schizophrenia.
What does depot suspension mean?
A depot injection is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication. They are designed to increase medication adherence and consistency, especially in patients who commonly forget to take their medicine.
What is meant by depot preparation?
A preparation of a medicine in which the active ingredients are released slowly into tissue. From: depot preparation in The Oxford Dictionary of Sports Science & Medicine » Subjects: Medicine and health — Clinical Medicine.
Who invented clozapine?
Clozapine was synthesised and characterised by Swiss pharmaceutical company Wander (now part of Novartis) in 1956 — only six years after the first-generation drug, chlorpromazine, was discovered in the laboratories of Rhône-Poulenc (now part of Sanofi-Aventis).
How are depot injections made?
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions.
How was the first antipsychotic drug discovered?
In 1951, Laborit and Huguenard administered the aliphatic phenothiazine, chlorpromazine, to patients for its potential anesthetic effects during surgery. Shortly thereafter, Hamon et al. and Delay et al. extended the use of this treatment in psychiatric patients and serendipitously uncovered its antipsychotic activity.
What is the mean of Depot?
Definition of depot 1a : a place for storing goods or motor vehicles. b : store, cache a fat depot in the body. 2a : a place for the storage of military supplies. b : a place for the reception and forwarding of military replacements. 3 : a building for railroad or bus passengers or freight.
What’s depot short for?
DEPOT
| Acronym | Definition |
|---|---|
| DEPOT | Dot Enumeration Perceptual Organization Task |
How do you administer antipsychotic depot?
Choice of injection site Most oil-based depot antipsychotic injections must be administered only into the gluteal muscle by deep intramuscular (IM) injection. The exceptions to this are flupentixol and zuclopenthixol depots which are also licensed to be administered via the lateral thigh.
Which are the different types of depot injections?
Antipsychotic depot injections
| Antipsychotic depot injections | Preparations |
|---|---|
| Aripiprazole | 400mg injection |
| Flupentixol decanoate | 20mg/ml, 40mg/2ml, 50mg/0.5ml, 100mg/1ml, 200mg/ml injection |
| Haloperidol decanoate | 50mg/ml, 100mg/ml injection |
| Paliperidone palmitate 1-monthly(Xeplion®) | 50mg, 75mg, 100mg, 150mg pre-filled syringes |
Where does clozapine come from?
What is depot antipsychotic medication?
What is depot antipsychotic medication? It is a special preparation of the medication, which is given by injection. The medication is slowly released into the body over a number of weeks. It is important to know that the medication going into your body by a depot injection is exactly the same as the medication going into your body in tablet form.
What are the different types of depot medications?
Most depot medications belong to the older group of antipsychotics (‘first generation’ or ‘typical’ antipsychotics). These are Modecate, Depixol, Haldol, Piportil and Clopixol.
What is a depot injection?
It is a special preparation of the medication, which is given by injection. The medication is slowly released into the body over a number of weeks. It is important to know that the medication going into your body by a depot injection is exactly the same as the medication going into your body in tablet form.
How many first-generation and second-generation depot antipsychotics are there?
Although there are currently 5 first-generation and 6 second-generation depot antipsychotics available worldwide, many physicians are still reluctant to use this category of drug initially.