What is Tolazoline used for?
In human medicine, tolazoline is 185 used to treat hypotension, hypertension, newborn respiratory distress, and congenital heart disease 186 through interactions with α2-adrenergic and histamine receptors (Grover et al.
What type of drug is Tolazoline?
Tolazoline is a nonselective vasodilator that has been used for several decades to treat pulmonary hypertension in neonates. Its primary action appears to be as a competitive α-adrenergic antagonist.
Which ring is present in Tolazoline?
Tolazoline is a member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group. It has a role as an alpha-adrenergic antagonist, an antihypertensive agent and a vasodilator agent. A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output.
Is Tolazoline act as hypnotic?
Abstract. The alpha2-adrenergic receptor antagonists, yohimbine, atipamezole and tolazoline, are used in veterinary medicine as reversal agents for the sedative/hypnotic effects of alpha2-agonists.
What is the brand name of Tolazoline?
Tolazoline, also known as priscoline, was used in treatment of persistent pulmonary hypertension of the newborn.
What can you not take with phenobarbital?
Some products that may interact with this drug include: darunavir, etravirine, orlistat, rilpivirine. Other medications can affect the removal of phenobarbital from your body, which may affect how phenobarbital works. Examples include St. John’s wort, among others.
What are the physiological effects of phenobarbital?
SIDE EFFECTS: Dizziness, drowsiness, excitation, headache, tiredness, loss of appetite, nausea, or vomiting may occur as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
How does phentolamine affect the heart?
1 Intravenously administered phentolamine provoked immediate decreases in diastolic blood pressure but increases in heart rate and cardiac output.
What are the side effects of phentolamine?
Common side effects of phentolamine mesylate for injection include:
- acute and prolonged hypotensive episodes.
- fast heart rate.
- cardiac arrhythmias.
- weakness.
- dizziness.
- flushing.
- dizziness upon standing (orthostatic hypotension)
- stuffy nose.
Why is phentolamine given?
Phentolamine is used parentally to reverse vasoconstriction resulting from release of catecholamines that occurs during surgery for pheochromocytoma, and to prevent or treat dermal necrosis during intravenous infusion of norepinephrine. Intracavernosal phentolamine has been used to treat erectile dysfunction.
Is phenobarbital safe for newborns?
Phenobarbital is used to treat infants (ages 0-1 year) with any type of seizure disorder, and other children with generalized, partial or febrile seizures. It is also used for treatment of status epilepticus (seizures lasting greater than 15 minutes).
How does phenobarbital treat jaundice?
The major effect of phenobarbital is to increase hepatic glucuronosyl transferase (UGT) activity and the conjugation of bilirubin, apart from possibly enhancing hepatic uptake of bilirubin. Several studies have evaluated the effect of phenobarbital on nonpathologic, indirect hyperbilirubinemia.
What is phentolamine the antidote for?
Phentolamine mesylate: the antidote for vasopressor extravasation.
How does phentolamine cause reflex tachycardia?
In contrast, the blood pressure lowering effects of non-selective alpha blockers, such as phentolamine, are associated with a marked reflex tachycardia due to blunting of inhibitory presynaptic α2 feedback that suppresses the release of norepinephrine when synaptic levels of the neurotransmitter rise.
What is a side effect of phentolamine?
Common side effects of phentolamine include injection site pain, headache, and changes in heart rate. Phentolamine can also cause dizziness. Do not drive or operate heavy machinery until you know how phentolamine affects you.