What is the normal range for beta-2 microglobulin?
Normal findings : Blood: 0.70-1.80 mcg/mL. Urine: ≤300 mcg/L.
What is a high M spike?
A monoclonal spike (M spike or paraprotein) on serum protein electrophoresis (SPEP) is a frequent finding in the general population and typically is pathognomonic of an asymptomatic, premalignant condition called monoclonal gammopathy of undetermined significance (MGUS).
Is beta-2 microglobulin the same as beta globulin?
Examples of beta globulins include: beta-2 microglobulin.
What is the normal range for gamma globulin?
Gamma globulin: 0.7 to 1.6 g/dL or 7 to 16 g/L.
What is normal beta globulin?
Beta globulin: 0.7 to 1.2 g/dL or 7 to 12 g/L.
What is high beta globulin?
Healthcare providers use globulin blood tests to measure protein levels in your blood. Your liver makes globulin, a protein. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease.
What is high beta 2 microglobulin in a multiple myeloma?
People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.
What is considered high beta 2 microglobulin?
What is considered a high beta-2 microglobulin? Beta 2 microglobulin level is elevated in the plasma of 75% of patients with multiple myeloma at the time of diagnosis. Patients with serum beta 2 microglobulin levels less than 4 ug/ml have a better prognosis than those with levels greater than 4 ug/mL.
What does it mean when Beta 2 globulin is high?
When Beta 2 micro globulin is detectable in the urine, it is already considered to be at a high enough level to be noted as a sign of some problem. Beta 2 micro globulin level is a marker for tumors, disease, and kidney function problems.
What does elevated beta 2 globulin mean?
Elevated beta 2 microglobulin in the blood is correlated with a larger amount of tumor (tumor mass) and reduced kidney function in multiple myeloma patients. Recently, the International Myeloma Working Group published new guidelines called the International Staging System for Multiple Myeloma.
What causes elevated beta globulin levels?
Beta globulins.Elevated beta-globulin levels may be indicative of chronic liver or kidney disease, or chronic inflammatory diseases such as aspergillosis or avian chlamydiosis.The most common reason for elevated beta globulins in birds, which is attributable to the transferrin component, is egg production.