What is the difference between overall survival and progression-free survival?
Progression-free survival (PFS), the time from treatment initiation until disease progression or worsening, may be used as a direct or surrogate measure of clinical benefit for drug approvals, depending on the disease and response observed, while overall survival (OS), the duration of patient survival from the time of …
Is disease free survival the same as overall survival?
Unlike progression-free survival in the advanced cancer setting, which refers to time from treatment to disease progression (or death) in patients who already have measurable cancer in their bodies, DFS refers to time from treatment until the recurrence of disease (or death) after undergoing curative-intent treatment.
How do you calculate overall survival rate?
It is calculated by dividing the percentage of patients with the disease who are still alive at the end of the period of time by the percentage of people in the general population of the same sex and age who are alive at the end of the same time period.
What is progression-free survival rate?
Progression-free survival rate. The percentage of people who did not have new tumor growth or cancer spread during or after treatment. The disease may have responded to treatment completely or partially, or the disease may be stable. This means the cancer is still there but not growing or spreading.
What is progression free survival rate?
What is meant by progression free survival?
Listen to pronunciation. (pruh-GREH-shun ser-VY-vul) The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse.
Why is PFS2 important?
PFS2 is a useful endpoint to highlight whether the natural history of the disease is worsened by the study drug or not, and to demonstrate that there can be benefit beyond initial disease progression[4].
Is progression-free survival a good endpoint?
Compared with os, pfs is an attractive endpoint in clinical trials because it is available earlier, is less influenced by competing causes of death, and is uninfluenced by crossover and subsequent lines of therapy.
How is PFS rate calculated?
Patient without PD/Death Event This patient censoring date is on 2018-06-06 at visit=WEEK 16 since this date is the last tumor response evaluation date. The PFS value is calculated as 117 days (RSDTC – RANDDT+1).
What is progression-free survival in clinical trials?
The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse. In a clinical trial, measuring the progression-free survival is one way to see how well a new treatment works. Also called PFS.