What is polymorphism in pharmaceuticals?

What is polymorphism in pharmaceuticals?

Polymorphism occurs when a chemical compound crystallizes with different internal structures. ICH Q6A defines polymorphism as “some new drug substances exist in different crystalline forms which differ in their physical properties.

What is polymorphism in chemistry PDF?

Polymorphism. It is the phenomenon in which the same chemical substance exhibits different internal crystal packing arrangements. Polymorphs have distinct : (i)Crystal structures (mutual arrangements of molecules, atoms or ions).

What is polymorphism in solid state?

Polymorphism is a common phenomenon of crystalline materials. It describes the ability of a substance to exist as two or more crystalline phases that have different arrangements of the molecules in the solid state but are otherwise identical in terms of chemical content.

What is the importance of polymorphism?

Polymorphism is considered one of the important features of Object-Oriented Programming. Polymorphism allows us to perform a single action in different ways. In other words, polymorphism allows you to define one interface and have multiple implementations.

What is polymorphism in phase diagram?

Polymorphism is when a solid material can exist in more than one form or crystal structure. Polymorphism is very similar to Allotropy, but they should not be confused, polymorphism describes molecules, while Allotropy is used to describe atoms.

What are the principles of polymorphism?

The dictionary definition of polymorphism refers to a principle in biology in which an organism or species can have many different forms or stages. This principle can also be applied to object-oriented programming and languages like the Java language.

What is the application of polymorphism?

Application of Polymorphism Polymorphism is very useful in the pharmaceutical field for the development of a drug. The structure of the solid crystal is important to determine the effectiveness of the drug and the effects it can have on the body.

What is the importance of polymorphism in pharmaceutical compounding?

Polymorphism is an influential phenomenon especially in pharmaceutical sciences, as it can significantly influence variety of API properties including flowability, tableting, dissolution rate, solubility, stability and even biological performance including efficacy and toxicity [4, 88-90].