What is a renal oncocytoma?
Renal oncocytomas are common benign kidney neoplasms that account for 3 to 7 percent of renal neoplasms. They usually occur in adults, most frequently in the seventh decade of life. Renal oncocytomas may be discovered incidentally or may be diagnosed with biopsy or excision.
Why is it called chromophobe RCC?
Chromophobe RCC was first reported in 1985; its name was derived from the morphologic similarity between the predominant tumor cells in the human tumor to those comprising the experimentally produced rat kidney tumor.
What is chromophobe renal cancer?
Chromophobe renal cell carcinoma is a rare type of kidney cancer that forms in the cells lining the small tubules in the kidney. These small tubules help filter waste from the blood, making urine. As the different types of kidney cancer are very distinct, characterizing and understanding each type is important.
Is chromophobe renal cell carcinoma curable?
However, the good news is that many people diagnosed with chromophobe renal cell carcinoma can be completely cured.
What is malignant oncocytoma?
An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant.
Can oncocytoma become malignant?
Renal oncocytoma is a type of kidney tumor that is typically not cancerous but may have the ability to become malignant.
How common is chromophobe renal cell carcinoma?
Chromophobe RCC (chRCC) is the third most common subtype of RCC, accounting for 5% of RCC cases (Rini et al., 2009). It is estimated at approximately 3700 new cases in 2020 in the USA (Siegel et al., 2020).
How fast does chromophobe renal cell carcinoma grow?
The researchers found that 98% of the 95 lesions (81 oncocytoma, 14 chromophobe renal cell carcinoma) included in the analysis were diagnosed on biopsy. During a median follow-up of 34 and 25 months, respectively, the annual growth rate was 0.14 cm for oncocytoma and 0.38 cm for chromophobe renal cell carcinoma.
What is the survival rate of chromophobe renal cell carcinoma?
The aggregate literature suggests that chromophobe renal cell carcinoma (RCC) is biologically a tumor of low malignant potential with reported 5-year and 10-year survival rates of 78% to 100% and 80% to 90%, respectively.
Is renal oncocytoma malignant?
Renal oncocytoma is a noncancerous (benign) growth in one or both of your kidneys.
Should renal oncocytoma be removed?
Do benign kidney tumors need to be removed? Renal oncocytomas that don’t grow or cause problems may not need treatment. Your healthcare provider may recommend surgery if the diagnosis is uncertain or you have symptoms. Surgery may remove only the mass (partial nephrectomy) or the entire kidney (radical nephrectomy).
Is oncocytoma a neoplasm?
An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant….
| Oncocytoma | |
|---|---|
| Specialty | Oncology |
What are the chromophobe cells?
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope. Chromophobe cells are one of three cell stain types present in the anterior and intermediate lobes of the pituitary gland, the others being basophils and acidophils.
What is the most common site of metastasis for RCC?
Patterns of metastases in RCC The most common sites of metastases were lung (45%), following by bone (30%) and lymph node (22%). Liver metastases were noted in 20% of patients and adrenal metastases were noted in 9% of patients.
Can oncocytoma be malignant?
Can renal oncocytomas become malignant (cancerous)? Renal oncocytomas are unlikely to become cancerous. However, studies have found rare instances where people with renal oncocytomas with no known history of cancer develop metastatic cancer in their liver or bones.
Is oncocytoma a renal cell carcinoma?
A person with renal oncocytoma has a noncancerous (benign) mass in one or both of their kidneys. When symptoms occur, they mimic renal cell carcinoma, a type of kidney cancer. Surgery to remove and biopsy the tumor is the only way to diagnose renal oncocytomas.
What is the difference between chromophils and Chromophobes?
Chromophobes are undifferentiated or resting chromophils that appear weakly stained with smaller nuclei and less distinct borders.
Where is chromophobe found?
the pituitary gland
Chromophobe cells are one of three cell stain types present in the anterior and intermediate lobes of the pituitary gland, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary.
How long can you live with metastatic renal cell carcinoma?
Untreated patients with metastatic RCC have a median survival of 6 to 12 months and a 5-year survival rate of < 20%. Shorter interval between nephrectomy and the development of metastases is associated with a poorer prognosis [4]. Late tumor recurrence occasionally occurs many years after initial treatment.