What does it mean when monoclonal protein detected?
An antibody found in unusually large amounts in the blood or urine of people with multiple myeloma and other types of plasma cell tumors. Also called M protein.
What is IgA lambda monoclonal gammopathy?
Monoclonal gammopathy of undetermined significance (MGUS) is a disorder in which there is an increased production and accumulation of an abnormal protein, monoclonal protein (M protein), by plasma cells in the bone marrow [1]. There are two subtypes of this disease, IgM MGUS and non-IgM MGUS.
What does monoclonal immunoglobulin detected mean?
Overview. Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood. This abnormal protein is formed within your bone marrow, the soft, blood-producing tissue that fills in the center of most of your bones.
What does it mean no monoclonal protein detected?
If a monoclonal protein is identified, its immunoglobulin class (IgG, IgA, IgM, IgD, IgE) and light chain type (kappa, lambda) are determined by immunofixation. If no monoclonal protein is detected, further testing is not warranted.
What causes monoclonal proteins?
The exact cause of MGUS is not known. Infection, immune system problems, and the environment may play a role. But experts have not found a clear link yet. Experts do know that the abnormal proteins are not caused by a certain diet or from eating dietary proteins.
What is usually the first early symptom of multiple myeloma?
The early signs, which can vary among individuals, include: Bone pain (particularly in the spine and ribs) Excessive bruising or bleeding. Unexplained bone fractures (especially in the spinal vertebrae)
What are the warning signs of myeloma?
Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none….When signs and symptoms do occur, they can include:
- Bone pain, especially in your spine or chest.
- Nausea.
- Constipation.
- Loss of appetite.
- Mental fogginess or confusion.
- Fatigue.
- Frequent infections.
- Weight loss.
How do you feel with myeloma?
You might feel: Sudden, severe back pain. Numbness or weakness, often in your legs. Muscle weakness, often in your legs….This can slow blood flow to your brain and lead to:
- Confusion.
- Dizziness.
- Symptoms of a stroke, like drooping on one side of your face, weakness or numbness in one arm, and slurred speech.
Should I worry about MGUS?
Treatment and follow-up for MGUS MGUS does not usually need treatment as it rarely causes any symptoms. In most people, MGUS remains stable and never causes any problems. There is a small risk of MGUS developing into a cancer, such as myeloma or lymphoma. If this happens, it can cause certain symptoms.
Does MGUS cause weight gain?
They analyzed data from 7,878 patients, most of whom were men, who were diagnosed with MGUS from October 1999 through December 2009. The patients consisted of 39.8 percent who carried extra weight and 33.8 percent who were obese.