What are the benefits of superoxide dismutase?
Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases.
What foods are high in superoxide dismutase?
What foods contain superoxide dismutase? Natural sources of superoxide dismutase include cabbage, peas, broccoli and spinach. You can also find SOD supplements, and it can be used intravenously by a health care professional.
How do you increase superoxide dismutase?
By strengthening the body’s primary antioxidant systems, novel SOD-boosting supplements may offer the most powerful free radical protection available today. The antioxidant enzymes produced within our bodies are complex proteins that often incorporate minerals such as selenium or zinc in their intricate structures.
Can superoxide dismutase be absorbed?
Superoxide dismutase (SOD) is an enzyme that is present throughout the body. It is available in the form of supplements, but these are not absorbed following oral administration (1).
What disease is associated with a lack of superoxide dismutase?
In mice, the extracellular superoxide dismutase (SOD3, ecSOD) contributes to the development of hypertension. Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic obstructive pulmonary disease (COPD).
How does superoxide damage cells?
Superoxide promotes hydroxyl-radical formation and consequent DNA damage in cells of all types. The long-standing hypothesis that it primarily does so by delivering electrons to adventitious iron on DNA was refuted by recent studies in Escherichia coli.
Where is SOD found?
SODs are commonly found in chloroplasts, mitochondria, peroxisomes, and cytoplasm of higher plants in three molecular forms, namely Mn-SOD, Cu/Zn-SOD, and Fe-SOD. In general, Mn-SOD is located in mitochondria and peroxisome, Fe-SOD in chloroplasts, and Cu/Zn-SOD in chloroplast and cytoplasm.
What food contains SOD?
The foods that are rich sources of SOD, such as broccoli, cabbage, or barley grass, are also good sources of the minerals (zinc, copper, and manganese) that our bodies use to make our own SOD, and this may possibly explain the slight boost in blood SOD from supplements.
What foods contain SOD?
How do I increase SOD naturally?
The cruciferous vegetables broccoli, cabbage and Brussels sprouts are naturally rich in SOD. They are also excellent sources of vitamin C and contain small amounts of essential trace minerals that boost SOD production, including copper, manganese and zinc.
What activates superoxide dismutase?
The activity of each of the superoxide dismutase families relies upon a specific redox active metal ion, and depending on the SOD molecules, this could either be a manganese, iron, copper or nickel ion.
Why is superoxide toxic?
Usually the toxicity of superoxide is attributed to its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species.
How does superoxide damage DNA?
Alternative proposals have suggested that superoxide may accelerate oxidative DNA damage by leaching iron from storage proteins or enzymic [4Fe-4S] clusters. The released iron might then deposit on the surface of the DNA, where it could catalyze the formation of DNA oxidants using other electron donors.
What drug is SOD?
Superoxide dismutase (SOD, orgotein) is an ubiquitous enzyme that has received attention because of its therapeutic activity and because of claims that its ingestion may improve health and lengthen the human lifespan.
What is SOD medicine?
Superoxide dismutase (SOD, orgotein) is an ubiquitous enzyme that has received attention because of its therapeutic activity and because of claims that its ingestion may improve health and lengthen the human lifespan. At least 3 distinct types of the enzyme are found in humans and other mammals.
What is the best source of superoxide dismutase?
Green Vegetables With SOD The cruciferous vegetables broccoli, cabbage and Brussels sprouts are naturally rich in SOD. They are also excellent sources of vitamin C and contain small amounts of essential trace minerals that boost SOD production, including copper, manganese and zinc.
How is superoxide produced in the body?
In cells, superoxide is produced from oxygen molecules by xanthine oxidase, NADPH oxidase and mitochondrial electron transfer systems. Superoxide produced in mitochondria is generated by electrons leaking from the electron transfer system, which is located in the inner membrane of mitochondria.
How is superoxide formed in the body?
What is Extramel?
Our Extramel® ingredient is a unique melon juice concentrate, obtained from a proprietary variety of Cantaloupe melon. Naturally rich in Superoxide Dismutase, Extramel® also contains a cocktail of all the bioactive molecules of melon: vitamins, minerals, proteins, fibers and sugars.