What are the 4 subtypes of leukemia?
There are 4 main types of leukemia, based on whether they are acute or chronic, and myeloid or lymphocytic:
- Acute myeloid (or myelogenous) leukemia (AML)
- Chronic myeloid (or myelogenous) leukemia (CML)
- Acute lymphocytic (or lymphoblastic) leukemia (ALL)
- Chronic lymphocytic leukemia (CLL)
What is the FAB classification of myelomonocytic leukemia?
The French-American-British (FAB) classification of AML
| FAB subtype | Name |
|---|---|
| M3 | Acute promyelocytic leukemia (APL) |
| M4 | Acute myelomonocytic leukemia |
| M4 eos | Acute myelomonocytic leukemia with eosinophilia |
| M5 | Acute monocytic leukemia |
How does interferon alpha work in CML?
Interferon-alpha is a man-made drug that acts like the substance our immune system naturally produces. It reduces the growth and division of leukemia cells. Interferon-alpha is the type most often used in treating chronic myeloid leukemia (CML).
How many leukemia subtypes are there?
Leukemia cells can be classified by the unique set of proteins found on their surface. These unique sets of proteins are known as “immunophenotypes.” Based on immunophenotyping of the leukemia cell, the World Health Organization (WHO) classifies ALL into two main subtypes.
What are the subtypes of AML leukemia?
Most people with AML have a subtype called myeloid leukemia, which means the cancer is in the cells that normally produce neutrophils. Other patients have a type of AML called monoblastic or monocytic leukemia. In monocytic leukemia, the cells look like white blood cells called monocytes.
What does interferon alpha do?
Interferon alfa stimulates T cells and other immune system cells to attack the cancer. It can also encourage cancer cells to send out chemicals that attract immune system cells to them.
What are the subtypes of ALL?
Subtypes of Acute Lymphocytic Leukemia (ALL) In the 1970s, a group of French, American, and British (FAB) leukemia experts divided ALL into 3 subtypes (L1, L2, and L3), based on the way the leukemia cells looked under the microscope after routine staining.
How many subtypes of AML are there?
One of the main things that differentiates AML from the other main forms of leukemia is that it has eight different subtypes, which are based on the cell that the leukemia developed from.
What are the stages of AML?
Acute Myeloid Leukemia (AML) Stages
- M0: Undifferentiated acute myeloblastic leukemia.
- M1: Acute myeloblastic leukemia with minimal maturation.
- M2: Acute myeloblastic leukemia with maturation.
- M3: Acute promyelocytic leukemia (APL)
- M4: Acute myelomonocytic leukemia.
- M4 eos: Acute myelomonocytic leukemia with eosinophilia.
What is FAB subtype?
The French-American-British (FAB) classification They classified AMLs into subtypes from M0 to M7. This was based on the type of cell from which the leukemia developed and the level of maturity of the cells. The FAB classification relied on appearance of leukemia cells under the microscope after routine staining.
Which subtype of AML is the most common?
Most people with AML have a subtype called myeloid leukemia, which means the cancer is in the cells that normally produce neutrophils. Other patients have a type of AML called monoblastic or monocytic leukemia.
What is AML M7 leukemia?
Abstract. Acute Megakaryoblastic Leukaemia (AML, M7) is a rare type of acute myeloid leukemia (AML) evolving from primitive megakaryoblasts. It accounted for 1.2% of newly diagnosed AML according to Eastern Cooperative Oncology Group (ECOG) trials between 1984 and 1997.
What produces IFN-alpha?
IFN-alpha is produced in the leukocytes infected with virus, while IFN-beta is from fibroblasts infected with virus. IFN-gamma is induced by the stimulation of sensitized lymphocytes with antigen or non-sensitized lymphocytes with mitogens.
How does alpha interferon help in the treatment of malignant tumors?
How interferon alfa works. Interferon alfa stimulates T cells and other immune system cells to attack the cancer. It can also encourage cancer cells to send out chemicals that attract immune system cells to them.
What is the FAB classification of AML?
The French-American-British (FAB) classification of AML. In the 1970s, a group of French, American, and British leukemia experts divided AML into subtypes, M0 through M7, based on the type of cell the leukemia develops from and how mature the cells are.
What are the prognostic factors of acute myeloid leukemia (AML)?
Acute Myeloid Leukemia (AML) Subtypes and Prognostic Factors 1 Chromosome (cytogenetic) abnormalities. AML cells can have many kinds of chromosome changes,… 2 Gene mutations. People whose leukemia cells have certain gene mutations may have a better… 3 Markers on the leukemia cells. If the leukemia cells have the CD34 protein and/or…
What are the subtypes of acute myeloid leukemia (AML)?
Subtypes M0 through M5 all start in immature forms of white blood cells. M6 AML starts in very immature forms of red blood cells, while M7 AML starts in immature forms of cells that make platelets.
Why is type I immunoglobulin A (IFN-1) not used in clinical use?
One reason for this restricted clinical use is that type I IFN belongs to a multigene family that includes 13 different IFN-α subtypes and IFN-β, whose individual anti-viral and immunomodulatory properties have so far not been investigated in detail to improve IFN therapy against viral infections in humans.