What are liposomes PPT?
Structurally, Liposomes are concentric bilayered vesicles in which an aqueous volume is entirely enclosed by a membranous lipid bilayers mainly composed of natural or synthetic phospholipids. • Liposomes is Greek words means ‘Lipo’ mean ‘Fat’ and ‘Somes’ mean ‘Body’.
How liposomes can facilitate drug delivery?
Liposomes are defined as phospholipid vesicles consisting of one or more concentric lipid bilayers enclosing discrete aqueous spaces. The unique ability of liposomal systems to entrap both lipophilic and hydrophilic compounds enables a diverse range of drugs to be encapsulated by these vesicles.
How is drug release from liposome?
Drug release can be influenced by both the membrane composition of the liposome and the choice of drug. In addition to environmental triggers, such as low pH and the presence of particular enzymes, external stimuli such as heat or ultrasound have gained attention in the clinic.
What is the function of liposome?
Liposomes are used for drug delivery due to their unique properties. In fact, they can contain a wide variety of hydrophilic and hydrophobic diagnostic or therapeutic agents, providing a larger drug payload per particle and protecting the encapsulated agents from metabolic processes.
What is the definition of liposome?
(LY-poh-SOH-mul) A drug preparation that contains the active drug inside very tiny, fat-like particles. This form is easier for the body to absorb and allows more drug to get to the target area of the body, such as a tumor.
What is a liposome and its function?
A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Membranes are usually made of phospholipids, which are molecules that have a head group and a tail group.
How are liposomes used to deliver drugs across the plasma membrane?
The lipid bilayer of the liposome can fuse with other bilayers (e.g., cell membrane), thus delivering the liposome contents. By making liposomes in a solution of DNA or drugs (which would normally be unable to diffuse through the membrane) they can be delivered past the lipid bilayer.
What are liposomes function?
What is the structure of liposome?
Structurally, liposomes are concentric bleeder vesicles in which a membranous lipid bilayer surrounds an aqueous volume. Typically, the bilayer lipid membrane comprise phospholipids containing a hydrophobic tail and a hydrophilic head (Rovira-Bru et al., 2002).
How do liposomes work?
They typically form after supplying enough energy to a dispersion of (phospho)lipids in a polar solvent, such as water, to break down multilamellar aggregates into oligo- or unilamellar bilayer vesicles. Liposomes can hence be created by sonicating a dispersion of amphipatic lipids, such as phospholipids, in water.
What is meant by drug delivery?
Abstract. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance.
What is the importance of drug delivery system?
A drug delivery system is a formulation or a device that enables the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate, time and place of release of drugs in the body.
What is the aim of drug delivery?
Drug delivery aims to potentiate the therapeutic effect of medicinal drugs by conferring augmented physicochemical features upon them, for example, by overcoming the inherent instability of biologics, which impairs their pharmacokinetics.
What is drug delivery PDF?
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance.
What are the characteristics of drug delivery system?
Ideal characteristics of drug delivery systems It should increase the bioavailability of the drug. It should transport the drug intact to the site of action while avoiding the non-diseased host tissue. The product should be stable and delivery should be maintained under various physiological variables.