How long do you take isoniazid for TB?
To help clear up your tuberculosis (TB) completely, it is very important that you keep taking this medicine for the full time of treatment, even if you begin to feel better after a few weeks. You may have to take it every day for as long as 6 months to 2 years.
What are the contraindications of isoniazid?
Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug -induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology.
What is the most common side effect of isoniazid?
Common side effects may include: numbness, tingling, or burning pain in your hands or feet; nausea, vomiting, upset stomach; or. abnormal liver function tests.
What drugs interact with isoniazid?
Isoniazid interacts principally with anticonvulsants, theophylline, benzodiapines, paracetamol (acetaminophen) and some food. Fluoroquinolones can have absorption disturbance due to a variety of agents, especially the metal cations.
What are side effects of isoniazid?
Side Effects
- Clumsiness or unsteadiness.
- nausea or vomiting.
- numbness, tingling, burning, or pain in hands and feet.
- yellow eyes or skin.
What is the antidote for isoniazid?
Pyridoxine is the antidote for severe isoniazid poisoning and there is no specific antidote identified for rifampicin toxicity. Intravenous pyridoxine is recommended in large doses when symptoms of acute neurotoxicity develop with Isoniazid poisoning [3,4,5,6,7].
What foods to avoid while taking isoniazid?
Patients should be advised to avoid foods containing tyramine (e.g., aged cheese, cured meats such as sausages and salami, fava beans, sauerkraut, soy sauce, beer, or red wine) or histamine (e.g., skipjack, tuna, mackerel, salmon) during treatment with isoniazid.
What are the long term effects of isoniazid?
Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment. The risk for hepatitis increases with advancing age, concomitant alcohol use, chronic liver disease, and injection drug use.
What is the best time to take isoniazid?
Take isoniazid on an empty stomach, at least 1 hour before or 2 hours after a meal. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.
Why do we give vitamin B6 in TB patients?
Vitamin B6 is used to prevent numbing and tingling of the hands or feet sometimes caused by isoniazid or other TB medicines.
Can isoniazid cause seizures?
The ingestion of toxic amounts of isoniazid causes recurrent seizures, profound metabolic acidosis, coma and even death. In adults, toxicity can occur with the acute ingestion of as little as 1.5 g of isoniazid. Doses larger than 30 mg per kg often produce seizures.
What does isoniazid do to the body?
Isoniazid is in a class of medications called antituberculosis agents. It works by killing the bacteria that cause tuberculosis.
Why is B6 taken with isoniazid?
Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.