Can you take acyclovir while pregnant second trimester?
All formulations of acyclovir are assigned FDA pregnancy category C status ****, which indicates that safety in human pregnancies has not been determined; therefore, the drug should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Can acyclovir cause bleeding?
easy bruising or bleeding, purple or red pinpoint spots under your skin; changes in behavior; confusion, hallucinations; or.
What happens if you take acyclovir while pregnant?
Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.
Does acyclovir pass through placenta?
Acyclovir is known to cross the placenta to the fetus. Frenkel et al4 reported the specific pharmacokinetics of acyclovir in pregnant patients with recurrent HSV receiv ing either 200 or 400 mg of acyclovir orally every 8 hours from 38 weeks’ gestation until delivery.
Can you take valacyclovir in third trimester?
Evidence-Based Answer Pregnant women with a primary or recurrent episode of genital HSV infection who are later than 36 weeks of gestation should be treated with acyclovir (Zovirax) or valacyclovir (Valtrex) for viral suppression. (Strength of Recommendation [SOR]: A, based on one systematic review.)
What happens when you take too much acyclovir?
Low red blood cells and platelets: This drug may cause thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). These conditions cause dangerously low levels of red blood cells and platelets in your body. This may be fatal (cause death). Symptoms can include fatigue and low energy.
Can valacyclovir make you bleed?
Serious side effects may be more likely in adults who are 65 or older. Stop taking valacyclovir and call your doctor right away if you have any of the following signs of a serious side effect that can harm red blood cells: fever, pale skin; unusual bleeding (nosebleeds, bleeding gums);
Can you take acyclovir 400 mg while pregnant?
Both the American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention recommend the following dosages during pregnancy: acyclovir: 400-mg doses three times per day.
Is acyclovir safe at 36 weeks pregnant?
Acyclovir (a drug used to reduce genital herpes infection) when given to pregnant women with genital herpes from the 36 week causes reduction of undesirable outcomes to the mother or baby, although its effect when given earlier in pregnancy was undocumented.
Can you just stop taking acyclovir?
Take or use acyclovir until you finish the prescription, even if you feel better. If you stop taking acyclovir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat.
Does acyclovir cause blood clots?
Low red blood cells and platelets: This drug may cause thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). These conditions cause dangerously low levels of red blood cells and platelets in your body.
Is valacyclovir safe while pregnant?
Long-term suppressive therapy can significantly reduce these outbreaks and is likely safe during pregnancy. Acyclovir (Zovirax) and valacyclovir (Valtrex) are the drugs most commonly used for herpes outbreak suppression and treatment during pregnancy. These drugs help reduce how active the virus is.
Can I just stop taking acyclovir?
What are the long term side effects of acyclovir?
Serious side effects and their symptoms can include the following:
- Unusual changes in your mood or behavior. Symptoms can include:
- Decrease in your red blood cells and platelets. Symptoms can include:
- Liver problems.
- Muscle pain.
- Skin reactions.
- Changes in your vision.
- Kidney failure.
- Allergic reaction.
How long does acyclovir stay in your system after you stop taking it?
Because valacyclovir is a prodrug, it’s only active in your body for a short period of time after it’s taken. On its own, its half-life is approximately 30 minutes. However, once valacyclovir has converted into acyclovir, it has a half-life of 2.5 to 3.3 hours in people with normal renal function.
How much acyclovir is too much?
If you take more Aciclovir Tablets than you should Aciclovir 800 mg Tablets are not usually harmful, unless you take too much over several days. Talk to your doctor or pharmacist if you take too much Aciclovir 800 mg Tablets.
What are the risks of acyclovir during pregnancy?
Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety. This drug has not been studied prospectively in large numbers of pregnant women and lacks the Food and Drug Administration’s approval for gestational use unless benefits clearly outweigh potential fetal harm.
How many Michigan pregnant women have been exposed to acyclovir?
In a review of 229,101 deliveries to Michigan Medicaid patients, 391 first trimester exposures to acyclovir and 1081 exposures any time during pregnancy were recorded. These exposures included systemic and nonsystemic exposures.
Is acyclovir teratogenic in humans?
This drug was not teratogenic in mouse, rabbit, or rat at exposures greatly more than human exposure. In a review of 229,101 deliveries to Michigan Medicaid patients, 391 first trimester exposures to acyclovir and 1081 exposures any time during pregnancy were recorded. These exposures included systemic and nonsystemic exposures.
Can you take acyclovir while breastfeeding?
Acyclovir Breastfeeding Warnings. Adverse effects in breast-feeding infants associated with exposure to this drug via breast milk have not been reported in the literature. With the highest maternal dosage, the expected infant dose is about 1% of a typical infant dose.