Are COMT and Mao the SAMe?
Catechol-O-methyltransferase (COMT) and/or MAO (monoamine oxidase) further catalyze the metabolism of monoamines. Sympathetic nerves contain only MAO, but adrenal chromaffin cells contain both MAO and COMT. The COMT enzyme is distributed in all organs.
What do COMT and Mao do?
Either monoamine oxidase A (MAO) or catechol-O-methyltransferase (COMT) can catalyze the first step in catecholamine catabolism. MAO is located on the outer membranes of mitochondria and thus, in brain, is present primarily in nerve terminals and glia.
What is Mthfr COMT?
Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme involved in one-carbon metabolism17. The reduction of MTHFR activity may compromise DNA methylation18. Therefore, genetic variations of the MTHFR gene might affect COMT methylation and COMT function.
Does COMT affect methylation?
These results indicate that there is an association between substance use and COMT gene methylation. Although this association is complex, combining genetic and epigenetic variation of the COMT gene may be helpful in further elucidating the influence of the dopamine system on substance use in adolescence.
How do you treat low COMT activity?
Treating lower levels of COMT: Adequate B6, B12, folate and betaine to support formation of S-adenosylmethionine and prevent elevated homocysteine; S-adenosylhomocysteine inhibits COMT activity. DIM if you have high estrogens because estrogens inhibit COMT.
How do you fix COMT gene?
1. Because COMT is a methylation gene, it’s essential to get adequate B vitamins to support COMT, especially B2, B6, B9, and B12 as well as magnesium. To support COMT methylation, others suggest people with COMT Met/Met also take SAMe.
How does COMT affect dopamine?
The catechol-O-methyl transferase (COMT) enzyme degrades catecholamines, including dopamine. A single nucleotide polymorphism in the human COMT gene (Val158) increases the thermostability of the enzyme—thereby increasing its level of activity compared to the 158Met allele (Chen et al.
How do you know if you have the MAOA gene?
The Genetics A simple DNA test can be done to find out which single form of MAOA a male has inherited and which two forms a female has inherited. The MAOA gene is located on the X-chromosome. Men inherit only one X chromosome, so they have only one version of MAOA.
How do you fix a slow COMT gene?
COMT is a methylation gene, which means you can take supplements to support its function. The most helpful are: B vitamins, particularly B2, B6, B9, and B12. But always be aware of the possibility of overstimulation if you have AFS and are very sensitive.
What does COMT do in the brain?
COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158.
How do I know if I have the MAOA gene?
What are some tips for people with Mao and COMT?
People with MAO and COMT are going to have a difficult time sleeping after a workout that ends at 8 or 9 pm. We can do that when we are 10 years old, but the older we get, the more sensitive we become. 3) Get 8-9 hours of sleep. Most people need 7 hours minimum.
What are MAO-A and COMT?
The genes mainly responsible for these behaviors are called MAO-A and COMT . People with MAO and COMT are predisposed to simply have TOO MUCH ADRENALIN in the body.
What are Mao and COMT and why are they so dangerous?
People with MAO and COMT are predisposed to simply have TOO MUCH ADRENALIN in the body. When we are born with COMT or MAO A SNPs it means those enzymes are SLOWED DOWN in the body – current research has proven that COMT and MAO-A SNPs slow down these important chemical processes.
What are Mao and COMT SNPs and why do they matter?
People with MAO and COMT are predisposed to simply have TOO MUCH ADRENALIN in the body. When we are born with COMT or MAO-A SNPs it means those enzymes are SLOWED DOWN in the body – current research has proven that COMT and MAO-A SNPs slow down these important chemical processes.